ACE inhibitors and anaphylactoid reactions to high-flux membrane dialysis (AN69): clinical aspects.
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چکیده
منابع مشابه
Role of bradykinin in anaphylactoid reactions during hemodialysis with AN69 dialyzers.
In vitro experiments have related anaphylactoid reactions in patients treated with angiotensin-converting enzyme (ACE) inhibitors during dialysis with AN69 membranes to excessive bradykinin generation using this negatively charged dialysis membrane. In the present clinical trial plasma bradykinin levels were followed during the early phase of dialysis in 10 patients, not being treated with ACE ...
متن کاملBradykinin is a mediator of anaphylactoid reactions during hemodialysis with AN69 membranes.
Anaphylactoid reactions (AR) are the most feared complications of hemodialysis. Recently, a high incidence of AR has been reported during dialysis with AN69 membranes in patients treated with ACE inhibitors. Plasma levels of C3a, histamine and bradykinin were measured in 12 patients at the onset of AR during dialysis with AN69. We also investigated bradykinin generation in 10 symptom-free patie...
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Acute reactions to the haemodialysis membrane have been reported as early as 1975 [1]. Because their severity is usually mild, their frequency is probably widely underestimated. However, these reactions may occasionally be life-threatening [2]. The aetiological mechanisms of these reactions are multiple, the best characterized being allergy to ethylene oxide and combined exposure to the polyacr...
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Haemodialysis (HD)-associated anaphylactic and anaphylactoid reactions are found to be a complex problem, and though they have been well-documented in literature, a number of unexplored aspects remain. Anaphylaxis is a severe, life-threatening, generalized or systemic form of hypersensitivity. The clinical diagnosis is based on case history and physical examination, and includes symptoms of air...
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عنوان ژورنال:
- Nephron
دوره 60 4 شماره
صفحات -
تاریخ انتشار 1991